From Hell, referring to the return address on a letter penned by the Ripper, is about people who are in hell, trying to survive the grimmest circumstances. At the core are five impoverished prostitutes who share a desperate friendship, drawn tighter as their ranks are terrorized by a gruesome murderer. Mary Kelly, Kate Eddowes, Liz Stride, Dark Annie Chapman and Polly exist on the brink, earning a meagre living with their bodies in a society that concurrently dishonours and feeds upon them. Owning virtually nothing of value, they are threatened by a monster that would steal from them their only possession: existence.